A broad-spectrum glutamatergic antagonist
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Product Type

Biochemicals

Research Area

Neuroscience

DL-AP4

Item No. 29011

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4-phosphono-butanoic acid
CAS Number
6323-99-5
Synonyms
  • NSC 30079
  • NSC 354086
Molecular Formula
C4H10NO5P
Formula Weight
183.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
OP(CCC(C(O)=O)N)(O)=O
InChi Code
InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
InChi Key
DDOQBQRIEWHWBT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $43

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    100 mg

    $81

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    250 mg

    $190

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    500 mg

    $355

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    Product Description

    DL-AP4 is a broad-spectrum glutamatergic antagonist.1 DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA (Item No. 14581), L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM.2 DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate (Item No. 14584), quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. White, W.F., Nadler, J.V., Hamberger, A., et al. Glutamate as transmitter of hippocampal perforant path. Nature 270(5635), 356-357 (1977).

    2. Evans, R.H., Francis, A.A., Hunt, K., et al. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br. J. Pharmacol. 67(4), 591-603 (1979).

    3. Nicoletti, F., Meek, J.L., Iadarola, M.J., et al. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. J. Neurochem. 46(1), 40-46 (1986).